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bibtexCitation bibtexEntryType title keywords url author journal year month day volume issue pages note abstract issn
ref1electronicThe crucial role of CS in systems and synthetic biologycomputer sciencehttp://portal.acm.org/citation.cfm?id=1342332
Bashor2008aarticleUsing Engineered Scaffold Interactions to Reshape MAP Kinase Pathway Signaling DynamicsBiotechhttp://www.sciencemag.org/cgi/content/abstract/319/5869/1539Bashor, Caleb ; Helman, Noah ; Yan, Shude ; Lim, WendellScience2008Mar1431958691539--154310.1126/science.1151153
Linshiz2008articleRecursive construction of perfect DNA molecules from imperfect oligonucleotidesDNA synthesishttp://www.nature.com/msb/journal/v4/n1/full/msb200826.htmlLinshiz, Gregory ; ben Yehezkel, Tuval ; Kaplan, Shai ; Gronau, Ilan ; Ravid, Sivan ; Adar, Rivka ; Shapiro, EhudMol Syst Biol2008May06410.1038/msb.2008.26
ref4electronicMain Page - 2008.igem.orggenomehttp://2008.igem.org/Main_PageiGEM is the premiere undergraduate Synthetic Biology competition. Student teams are given a kit of biological parts at the beginning of the summer. Working at their own schools over the summer, they use these parts and new parts of their own design to build biological systems and operate them in living cells. During the weekend of November 8-9, they present their work at the iGEM Competition Jamboree at MIT and have a chance to win awards. They add their new parts to the Registry of Standard Biological Parts for the students in the next year's competition.
ref5electronicPLoS Computational Biology: Biosynthetic Potentials of Metabolites and Their Hierarchical Organizationto readhttp://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1000049
ref6electronicPLoS Computational Biology: The Evolution of Robust Development and Homeostasis in Artificial Organismssynthetic biologyhttp://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1000030
Serrano2007articleSynthetic biology: promises and challengessynthetic biologyhttp://www.nature.com/msb/journal/v3/n1/full/msb4100202.htmlSerrano, LuisMol Syst Biol2007Dec18310.1038/msb4100202
Doktycz2007articleNano-enabled synthetic biologysynthetic biologyhttp://www.nature.com/msb/journal/v3/n1/full/msb4100165.htmlDoktycz, Mitchel ; Simpson, MichaelMol Syst Biol2007Jul10310.1038/msb4100165
Bashor2008barticleUsing Engineered Scaffold Interactions to Reshape MAP Kinase Pathway Signaling Dynamicssynthetic biologyhttp://www.sciencemag.org/cgi/content/full/319/5869/1539Bashor, Caleb ; Helman, Noah ; Yan, Shude ; Lim, WendellScience2008Mar1431958691539--154310.1126/science.1151153
Gibson2008articleComplete Chemical Synthesis, Assembly, and Cloning of a Mycoplasma genitalium GenomeVenterhttp://dx.doi.org/10.1126/science.1151721Gibson, Daniel G. ; Benders, Gwynedd A. ; Andrews-Pfannkoch, Cynthia ; Denisova, Evgeniya A. ; Baden-Tillson, Holly ; Zaveri, Jayshree ; Stockwell, Timothy B. ; Brownley, Anushka ; Thomas, David W. ; Algire, Mikkel A. ; Merryman, Chuck ; Young, Lei ; Noskov, Vladimir N. ; Glass, John I. ; Venter, J. Craig ; Hutchison, Clyde A. III ; Smith, Hamilton O.Science (New York, N.Y.)2008Jan2431958671151721--122010.1126/science.11517211095-9203
ref11electronicSynthetic Gene Circuits: Design with Directed Evolution - Annual Review of Biophysics and Biomolecular Structure, 36(1):1 - Abstractreviewhttp://arjournals.annualreviews.org/doi/abs/10.1146/annurev.biophys.36.040306.132600
ref12articleSynthetic Gene Circuits: Design with Directed EvolutionBioBrick Characterisationhttp://dx.doi.org/10.1146/annurev.biophys.36.040306.132600Annual Review of Biophysics and Biomolecular Structure2007xxxx361110.1146/annurev.biophys.36.040306.13260010568700
Sauro2008articleModularity definedsystems biologyhttp://www.nature.com/msb/journal/v4/n1/full/msb20083.htmlSauro, HerbertMol Syst Biol2008Feb12410.1038/msb.2008.3commentary on Del Vecchio et al (2008).
ref14electronicFrom the cells up | Science | The Guardiansynthetic biologyhttp://www.guardian.co.uk/science/2005/mar/10/science.research
ref15electronicLaying the foundations for a bio-economy 2008carlsonhttp://www.springerlink.com/content/n211746672413507/fulltext.pdf
ref16electronichackwriters.com - 21st Century Identity - Memory and Personality - Kim Pfieferemergent evolutionhttp://www.hackwriters.com/identity21.htmThe coming horrors of body-parts manufacture and cloning.
Benders2008articleComplete Chemical Synthesis, Assembly, and Cloning of a Mycoplasma genitalium Genomesynthetic biologyhttp://www.sciencemag.org/cgi/content/abstract/319/5867/1215?sa_campaign=Email/toc/29-February-2008/10.1126/science.1151721Benders, Gwynedd ; Hamilton, AndScience2008Jan24115172110.1126/science.1151721We have synthesized a 582,970 bp Mycoplasma genitalium genome. This synthetic genome, named M. genitalium JCVI-1.0, contains all the genes of wild-type M. genitalium G37 except MG408, which was disrupted by an antibiotic marker to block pathogenicity and to allow for selection. To identify the genome as synthetic, we inserted ``watermarks'' at intergenic sites known to tolerate transposon insertions. Overlapping ``cassettes'' of 5 to 7 kb, assembled from chemically synthesized oligonucleotides, were joined by in vitro recombination to produce intermediate assemblies of approximately 24 kb, 72 kb (``1/8 genome''), and 144 kb (``1/4 genome''), which were all cloned as bacterial artificial chromosomes (BACs) in Escherichia coli. Most of these intermediate clones were sequenced, and clones of all four 1/4 genomes with the correct sequence were identified. The complete synthetic genome was assembled by transformation-associated recombination (TAR) cloning in the yeast Saccharomyces cerevisiae, then isolated and sequenced. A clone with the correct sequence was identified. The methods described here will be generally useful for constructing large DNA molecules from chemically synthesized pieces and also from combinations of natural and synthetic DNA segments.
ref18electronicGenome stitched together by hand : Nature News - on article in Sciencesynthetic biologyhttp://www.nature.com/news/2008/080124/full/news.2008.522.htmlScientists have succeeded in stitching together an entire bacterial genome, creating in the lab the full set of instructions needed to make a living thing. The stage is now set for the creation of the first artificial organism — and it could be achieved within the year. The genome for the pathogenic bacterium Mycoplasma genitalium was made in the laboratory by Hamilton Smith and his colleagues at the J. Craig Venter Institute in Rockville, Maryland. The genome has 582,970 of the fundamental building blocks of DNA, called nucleotide bases, making it more than a factor of ten longer than the previous-longest stretch of genetic material created by chemical means.
ref19electronicETC Group -synthetic biologyhttp://www.etcgroup.org/en/Synthetic Biology Cartoons
Pennisi2008articleScientists Synthesize a Genome From Scratch - on article in Sciencesynthetic biologyhttp://sciencenow.sciencemag.org/cgi/content/full/2008/124/3Pennisi, ElizabethScienceNOW2008Jan2420081243Researchers have rebuilt an entire genome from scratch, they report online today in Science. Although the team has yet to demonstrate that this DNA can substitute for the real thing, the work paves the way for customized bacteria that could efficiently produce drugs, biofuels, and other molecules useful to humankind. Ever since his group decoded the genome of Mycoplasma genitalium, a parasitic bacterium that lives in the human urogenital tract, sequencing maverick J. Craig Venter has wanted to remake the bug's genome in the lab. At just under 600,000 bases, M. genitalium sports the smallest known genome for a free-living organism, and Venter hoped that an artificial genome could be modified to turn the bacterium into a living chemical-manufacturing plant.
ref21electronicScientists Take New Step Toward Man-Made Life - on article in Sciencesynthetic biologyhttp://www.nytimes.com/2008/01/24/science/24cnd-genome.htmlTaking a significant step toward the creation of man-made forms of life, researchers reported Thursday that they had manufactured the entire genome of a bacterium by painstakingly stitching together its chemical components. While scientists had previously synthesized the complete DNA of viruses, this is the first time it has been done for bacteria, which are much more complex. The genome is more than 10 times as long as the longest piece of DNA ever previously synthesized.
Sidney2007aarticleProgramming gene expression with combinatorial promotersPromoterhttp://www.nature.com/msb/journal/v3/n1/full/msb4100187.htmlSidney, Robert ; Cox, ; Surette, Michael ; Elowitz, MichaelMol Syst Biol2007Nov13310.1038/msb4100187
ref23articleSystems interface biologystochastichttp://dx.doi.org/10.1098/rsif.2006.0143Journal of The Royal Society Interface2006xxxx31060310.1098/rsif.2006.0143
Cox2007articleProgramming gene expression with combinatorial promoterssynthetic biologyhttp://www.nature.com/msb/journal/v3/n1/full/msb4100187.htmlCox, Robert Sidney ; Surette, Michael ; Elowitz, MichaelMol Syst Biol2007Nov13310.1038/msb4100187
ref25articleProgramming and engineering biological networkssynthetic biologyhttp://dx.doi.org/10.1016/j.sbi.2006.06.011Current Opinion in Structural Biology2006xxxx16455110.1016/j.sbi.2006.06.011
ref26electronicRegistry of Standard Biological Partsregistryhttp://parts.mit.edu/registry/index.php/Main_Page
ref27electronicBioMed Central | Abstract | 1752-0509-1-50 | Noise-induced switches in network systems of the genetic toggle switchnoisehttp://www.biomedcentral.com/1752-0509/1/50
Sidney2007barticleProgramming gene expression with combinatorial promoterssynthetic biologyhttp://www.nature.com/msb/journal/v3/n1/full/msb4100187.htmlSidney, Robert ; Cox, ; Surette, Michael ; Elowitz, MichaelMol Syst Biol2007Nov13310.1038/msb4100187
ref29articleNoise and kinetics of LuxR positive feedback loopssynthetic biologyhttp://dx.doi.org/10.1016/j.bbrc.2007.09.057Biochemical and Biophysical Research Communications2007xxxx363366710.1016/j.bbrc.2007.09.057
ref30articleDesign and implementation of three incoherent feed-forward motif based biological concentration sensorssynthetic biologyhttp://dx.doi.org/10.1007/s11693-007-9008-6Systems and Synthetic Biology2007xxxx10.1007/s11693-007-9008-618725325
ref31electronicBBC NEWS | Science/Nature | Creating life in the laboratorysynthetic biologyhttp://news.bbc.co.uk/2/hi/science/nature/7041353.stmThe race to create life version 2.0 is under way. The J Craig Venter Institute scientists are aiming to craft a ``minimal genome''- the smallest group of genes an organism needs to survive and function - and insert it into an empty cell. This stripped-down genome has been established with the help of a simple bacterium, Mycoplasma genitalium, by knocking out its genes, one by one, until only the genetic material vital for survival was found.
ref32articleExpanding the metabolic engineering toolbox: more options to engineer cellsBioBrick Characterisationhttp://dx.doi.org/10.1016/j.tibtech.2007.01.003Trends in Biotechnology2007xxxx25313210.1016/j.tibtech.2007.01.003
Wu2007articleOptimal encoding rules for synthetic genes: the need for a community effortsynthetic biologyhttp://www.nature.com/msb/journal/v3/n1/full/msb4100176.htmlWu, Gang ; Dress, Laura ; Freeland, StephenMol Syst Biol2007Sep18310.1038/msb4100176
Murphy2007aarticleCombinatorial promoter design for engineering noisy gene expression.synthetic biologyhttp://www.pnas.org/cgi/content/abstract/0608451104v1?maxtoshow=&HITS=1&hits=1&RESULTFORMAT=&andorexacttitle=and&titleabstract=synthetic+biology&andorexacttitleabs=and&andorexactfulltext=and&searchid=1&usestrictdates=yes&resourcetype=HWCIT&ctMurphy, Kevin ; Bal{\'a}zsi, G{\'a}bor ; Collins, JamesProceedings of the National Academy of Sciences of the United States of America2007Jul311043112726--1273110.1073/pnas.0608451104
Luisi2007articleChemical Aspects of Synthetic Biologysynthetic biologyhttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17443874&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlusLuisi, PierChemistry \& Biodiversity2007xxxx44603--62110.1002/cbdv.200790053
ref36articleSynthetic biology: lessons from the history of synthetic organic chemistrysynthetic biologyhttp://dx.doi.org/10.1038/nchembio0907-521Nature Chemical Biology2007xxxx39521--52110.1038/nchembio0907-521
ref37electronicPrather Group - Home PageLabhttp://web.mit.edu/prathergroup/index.htmlOur research is centered on the design and assembly of recombinant microorganisms for the production of small molecules. More simply, we are harnessing the synthetic power of biology to build microbial chemical factories. Current efforts include the development of tools and methodologies for novel biosynthetic pathway design and the investigation of gene dosage effects on the physiology and productivity of engineered microbes. Our research combines the traditions of metabolic engineering with the practices of biocatalysis to expand and optimize the biosynthetic capacity of microbial systems. A particular focus is the elucidation of design principles for the production of unnatural organic compounds within the framework of the nascent field of synthetic biology. Major Research Areas
Pedraza2005aarticleNoise propagation in gene networks.synthetic biologyhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15790857&query_hl=12Pedraza, Juan ; van Oudenaarden, AlexanderScience (New York, N.Y.)2005Mar2530757171965--196910.1126/science.1109090
Hooshangi2005aarticleUltrasensitivity and noise propagation in a synthetic transcriptional cascadeinverter compositionhttp://dx.doi.org/10.1073/pnas.0408507102Hooshangi, Sara ; Thiberge, Stephan ; Weiss, RonProceedings of the National Academy of Sciences2005Mar08102103581--358610.1073/pnas.0408507102
ref40electronicCell -- Deans et al.synthetic biologyhttp://www.cell.com/content/article/abstract?uid=PIIS0092867407006848
Murphy2007barticleCombinatorial promoter design for engineering noisy gene expressionsynthetic biologyhttp://www.pnas.org/cgi/content/abstract/0608451104v1?maxtoshow=&HITS=1&hits=1&RESULTFORMAT=&andorexacttitle=and&titleabstract=synthetic+biology&andorexacttitleabs=and&andorexactfulltext=and&searchid=1&usestrictdates=yes&resourcetype=HWCIT&ctMurphy, Kevin ; Balazsi, Gabor ; Collins, JamesProceedings of the National Academy of Sciences2007Jul311043112726--1273110.1073/pnas.0608451104
Grilly2007articleA synthetic gene network for tuning protein degradation in Saccharomyces cerevisiaesynthetic biologyhttp://www.nature.com/msb/journal/v3/n1/full/msb4100168.htmlGrilly, Chris ; Stricker, Jesse ; Pang, Wyming ; Bennett, Matthew ; Hasty, JeffMol Syst Biol2007Jul31310.1038/msb4100168
Waldminghaus2007articleGenome-wide bioinformatic prediction and experimental evaluation of potential RNA thermometers.synthetic biologyhttp://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17647020&itool=pubmed_DocSumWaldminghaus, Torsten ; Gaubig, Lena ; Narberhaus, FranzMol Genet Genomics2007Jul2410.1007/s00438-007-0272-7
ref44articleToward an artificial cell based on gene expression in vesicles.synthetic biologyhttp://www.ncbi.nlm.nih.gov/pubmed/16224117?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlusPhysical Biology2005xxxx231--110.1088/1478-3975/2/3/p01
Rinaudo2007aarticleA universal RNAi-based logic evaluator that operates in mammalian cellssynthetic biologyhttp://www.nature.com/nbt/journal/vaop/ncurrent/full/nbt1307.htmlRinaudo, Keller ; Bleris, Leonidas ; Maddamsetti, Rohan ; Subramanian, Sairam ; Weiss, Ron ; Benenson, YaakovNat Biotech2007Julxx257795--80110.1038/nbt1307
Szczepek2007articleStructure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases.zinc-finger nucleasehttp://www.nature.com/nbt/journal/vaop/ncurrent/abs/nbt1317.htmlSzczepek, Michal ; Brondani, Vincent ; B{\"u}chel, Janine ; Serrano, Luis ; Segal, David ; Cathomen, ToniNature biotechnology2007Julxx257786--79310.1038/nbt1317
Miller2007articleAn improved zinc-finger nuclease architecture for highly specific genome editing.Protein engineeringhttp://dx.doi.org/10.1038/nbt1319Miller, Jeffrey ; Holmes, Michael ; Wang, Jianbin ; Guschin, Dmitry ; Lee, Ya-Li ; Rupniewski, Igor ; Beausejour, Christian ; Waite, Adam ; Wang, Nathaniel ; Kim, Kenneth ; Gregory, Philip ; Pabo, Carl ; Rebar, EdwardNature biotechnology2007Julxx257778--78510.1038/nbt1319
Wang2007articleEvolved orthogonal ribosomes enhance the efficiency of synthetic genetic code expansion.orthogonalhttp://www.nature.com/nbt/journal/vaop/ncurrent/abs/nbt1314.htmlWang, Kaihang ; Neumann, Heinz ; Peak-Chew, Sew ; Chin, JasonNature biotechnology2007Julxx257770--77710.1038/nbt1314
Walter2007articleLight-powering Escherichia coli with proteorhodopsinproteorhodopsinhttp://dx.doi.org/10.1073/pnas.0611035104Walter, Jessica ; Greenfield, Derek ; Bustamante, Carlos ; Liphardt, JanProceedings of the National Academy of Sciences2007Feb1310472408--241210.1073/pnas.0611035104
Drubin2007aarticleDesigning biological systems.be theoryhttp://www.genesdev.org/cgi/content/full/21/3/242Drubin, David ; Way, Jeffrey ; Silver, PamelaGenes \& development2007Feb01213242--25410.1101/gad.1507207
Andrianantoandro2006aarticleSynthetic biology: new engineering rules for an emerging discipline.synthetic biologyhttp://www.nature.com/msb/journal/v2/n1/full/msb4100073.htmlAndrianantoandro, Ernesto ; Basu, Subhayu ; Karig, David ; Weiss, RonMolecular systems biology2006xxxx22006--002810.1038/msb4100073
Ball2007aarticleSynthetic biology: Designs for lifesynthetic biologyhttp://www.nature.com/nature/journal/v448/n7149/full/448032a.htmlBall, PhilipNature2007Jul05448714932--3310.1038/448032a
Ball2007barticleSynthetic biology: Designs for life - on article in Sciencesynthetic biologyhttp://www.nature.com/nature/journal/v448/n7149/full/448032a.htmlBall, PhilipNature2007Jul05448714932--3310.1038/448032aThe genome of one bacterium has been successfully replaced with that of a different bacterium, transforming one species into another. This development is a harbinger of whole-genome engineering for practical ends.
Yeh2007aarticleRewiring cellular morphology pathways with synthetic guanine nucleotide exchange factorsgtpasehttp://www.nature.com/nature/journal/vaop/ncurrent/abs/nature05851.htmlYeh, Brian ; Rutigliano, Robert ; Deb, Anrica ; Bar-Sagi, Dafna ; Lim, WendellNature2007May314477144596--60010.1038/nature05851
Lartigue2007aarticleGenome Transplantation in Bacteria: Changing One Species to Anothersynthetic biologyhttp://www.sciencemag.org/cgi/content/abstract/1144622Lartigue, Carole ; Glass, John ; Alperovich, Nina ; Pieper, Rembert ; Parmar, Prashanth ; Hutchison, III Clyde ; Smith, Hamilton ; Venter, J.Science2007Jun281144622--114462210.1126/science.1144622My comments: Venter and colleagues describe a method for replacing a chromosome in one bacteria by another from another bacteria (the two bacteria being distinct species, although {\textasciitilde}95\% identical at the genome level in this case). One of the challenges was in the extraction of intact, protein-free chromosomes from cells. The actual transfer then relies on polyethylene glycol (PEG), known to promote fusion of eukaryotic cells, but the actual transplantation mechanism is not understood. The authors hypothesize that two chromosome-free cells might fuse around a naked chromosome, with low frequency (but the resulting cells are selected using an antibiotics resistance gene). Nonetheless, this is clearly an important step forward for synthetic biology (you can imagine that entirely synthesized chromosomes will be inserted into empty host cells using this type of approaches).
ref56electronicScientists Report DNA Transplant - washingtonpost.com - on article in Sciencesynthetic biologyhttp://www.washingtonpost.com/wp-dyn/content/article/2007/06/28/AR2007062802046.htmlScientists said yesterday that they had transplanted a microbe's entire, tangled mass of DNA into a closely related organism, a delicate operation that cleanly transformed the recipient from one species into the other. After the operations, the ``patients'' -- single-celled organisms resembling bacteria -- dutifully obeyed their new genomes and by every measure exhibited the biological personas of the donors.
Pennisi2007articleGENETICS: Replacement Genome Gives Microbe New Identitysynthetic biologyhttp://www.sciencemag.org/cgi/content/full/316/5833/1827aPennisi, ElizabethScience2007Jun2931658331827--182710.1126/science.316.5833.1827aFor decades, molecular biologists have genetically modified microbes and other kinds of cells by adding short DNA sequences, whole genes, and even large pieces of chromosomes. Now, in a feat reported in a paper published online by Science this week (www.sciencemag.org/cgi/content/abstract/1144622), one group has induced a bacterium to take up an entire 1.08-million-base genome in one gulp. In doing so, microbiologist John Glass and his colleagues at the J. Craig Venter Institute in Rockville, Maryland, have transformed one bacterial species into another.
Lartigue2007barticleGenome Transplantation in Bacteria: Changing One Species to Anothersynthetic biologyhttp://www.sciencemag.org/cgi/content/abstract/1144622Lartigue, Carole ; Glass, John ; Alperovich, Nina ; Pieper, Rembert ; Parmar, Prashanth ; Hutchison, III Clyde ; Smith, Hamilton ; Venter, J.Science2007Jun281144622--114462210.1126/science.1144622As a step toward propagation of synthetic genomes, we completely replaced the genome of a bacterial cell with one from another species by transplanting a whole genome as naked DNA. Intact genomic DNA from Mycoplasma mycoides large colony (LC), virtually free of protein, was transplanted into Mycoplasma capricolum cells by polyethylene glycol-mediated transformation. Cells selected for tetracycline resistance, carried by the M. mycoides LC chromosome, contain the complete donor genome and are free of detectable recipient genomic sequences. These cells that result from genome transplantation are phenotypically identical to the M. mycoides LC donor strain as judged by several criteria.
ref59electronicGenome transplant makes species switch - on article in Sciencesynthetic biologyhttp://www.nature.com/news/2007/070625/full/070625-9.htmlBy transplanting their genomes, US scientists have converted one species into another. John Glass and his co-workers at the J. Craig Venter Institute in Rockville, Maryland, have taken DNA from a bacterium called Mycoplasma mycoides and inserted it into cells of the closely related species Mycoplasma capricolum. They find that the recipient cells with the new genome behave like those of the donor species, making protein molecules characteristic of the donor. It's like re-booting a cell with a new operating system, says Glass.
ref60articleMeanings of 'life'synthetic biologyhttp://www.nature.com/nature/journal/v447/n7148/full/4471031b.htmlNature2007Jun2844771481031--103210.1038/4471031b
Kaiser2007articleSYNTHETIC BIOLOGY: Attempt to Patent Artificial Organism Draws a Protestsynthetic biologyhttp://www.sciencemag.org/cgi/content/full/316/5831/1557Kaiser, JocelynScience2007Jun1531658311557--155710.1126/science.316.5831.1557An activist group's concern about maverick genome sequencer J. Craig Venter's intention to patent an entirely synthetic free-living organism has thrown a spotlight on the emerging intellectual-property landscape in this hot new field. The protesters claim that Venter wants his company to become the Microsoft of synthetic biology, dominating the industry.
ref62electronicMan-made microbe 'to create endless biofuel' | Uk News | News | Telegraphsynthetic biologyhttp://www.telegraph.co.uk/news/main.jhtml?xml=/news/2007/06/08/nbiofuel108.xmlA scientist is poised to create the world's first man-made species, a synthetic microbe that could lead to an endless supply of biofuel. Craig Venter, an American who cracked the human genome in 2000, has applied for a patent at more than 100 national offices to make a bacterium from laboratory-made DNA. It is part of an effort to create designer bugs to manufacture hydrogen and biofuels, as well as absorb carbon dioxide and other harmful greenhouse gases.
Rinaudo2007barticleA universal RNAi-based logic evaluator that operates in mammalian cellssynthetic biologyhttp://www.nature.com/nbt/journal/vaop/ncurrent/full/nbt1307.htmlRinaudo, Keller ; Bleris, Leonidas ; Maddamsetti, Rohan ; Subramanian, Sairam ; Weiss, Ron ; Benenson, YaakovNat Biotech2007May21advanced online publication10.1038/nbt1307
Dueber2007articleEngineering synthetic signaling proteins with ultrasensitive input/output controlsynthetic biologyhttp://www.nature.com/nbt/journal/vaop/ncurrent/abs/nbt1308.htmlDueber, John ; Mirsky, Ethan ; Lim, WendellNat Biotech2007Junxx256660--66210.1038/nbt1308
ref65electronicETC Group - Publications - Patenting Pandora’s Bug: Goodbye, Dolly...Hello, Synthia! J. Craig Venter Institute Seeks Monopoly Patents on the World’s First-Ever Human-Made Life Formsynthetic biologyhttp://www.etcgroup.org/en/materials/publications.html?pub_id=631The Venter Institute - named for its founder and CEO, J. Craig Venter, the scientist who led the private sector race to map the Human Genome - is applying for worldwide patents on what they refer to as ``Mycoplasma laboratorium.''
ref66electronicSecond Life, or Not? -- Kaiser 2007 (607): 3 -- ScienceNOWsynthetic biologyhttp://sciencenow.sciencemag.org/cgi/content/full/2007/607/3An activist group is raising a ruckus about what it says may be the first effort to patent an entirely synthetic free-living organism. It says the patent application, filed by maverick genome sequencer Craig Venter's institute on an idea that has likely not yet been achieved, would tie up a new technology and could aid bioterrorists. But others say there's nothing new or surprising about the patenting effort. The work involves a simple bacterium called Mycoplasma genitalium that Venter's eponymous institute in Rockville, Maryland, has been tinkering with for years. An early goal was to determine the minimum number of genes for life, and in 1999, scientists there published a rough tally. Now, they want to synthesize this ``minimal genome'' from scratch, get it working inside a cell, then add genes that would enable the bug to crank out hydrogen or ethanol to produce cheap energy.
Andrianantoandro2006barticleSynthetic biology: new engineering rules for an emerging discipline.synthetic biologyhttp://www.nature.com/msb/journal/v2/n1/full/msb4100073.htmlAndrianantoandro, Ernesto ; Basu, Subhayu ; Karig, David ; Weiss, RonMolecular systems biology2006xxxx22006--002810.1038/msb4100073
Yeh2007barticleRewiring cellular morphology pathways with synthetic guanine nucleotide exchange factorssynthetic biologyhttp://www.nature.com/nature/journal/vaop/ncurrent/abs/nature05851.htmlYeh, Brian ; Rutigliano, Robert ; Deb, Anrica ; Bar-Sagi, Dafna ; Lim, WendellNature2007May314477144596--60010.1038/nature05851
ref69electronicScientists Push the Boundaries of Human Life - Newsweek: International Editions - MSNBC.comsynthetic biologyhttp://www.msnbc.msn.com/id/18882828/site/newsweek/page/0/
ref70electronicSynthetic biology--putting engineering into biology -- Heinemann and Panke 22 (22): 2790 -- Bioinformaticssynthetic biologyhttp://bioinformatics.oxfordjournals.org/cgi/content/abstract/22/22/2790
ref71electronicMain Page - IGEMsynthetic biologyhttp://parts2.mit.edu/wiki/index.php/Main_PageThe international Genetically Engineered Machine competition iGEM is an international arena where student teams compete to design and assemble engineered machines using advanced genetic components and technologies. Learn more.
ref72electronicSynBERC - Synthetic Biology Engineering Research Centersynthetic biologyhttp://www.synberc.org/index.htmlConsortium of organizations to develop synthetic biology applocations, tools and ethics. Promoted by Drew Endy and George Church. also linked to the IGEM program.
ref73articleThe Generation of New Protein Functions by the Combination of Domainssynthetic biologyhttp://dx.doi.org/10.1016/j.str.2006.11.009Structure2007xxxx15185--8510.1016/j.str.2006.11.009
Chen2007articleA synthetic maternal-effect selfish genetic element drives population replacement in Drosophila.synthetic biologyhttp://www.sciencemag.org/cgi/content/abstract/1138595Chen, Chun-Hong ; Huang, Haixia ; Ward, Catherine ; Su, Jessica ; Schaeffer, Lorian ; Guo, Ming ; Hay, BruceScience (New York, N.Y.)2007Apr273165824597--60010.1126/science. 1138595
ref75articleA synthetic biology challenge: making cells computesynthetic biologyhttp://dx.doi.org/10.1039/b618473cMolecular BioSystems2007xxxx10.1039/b618473c
ref76articleMultiple High-Throughput Analyses Monitor the Response of E. coli to PerturbationsLab techniqueshttp://www.sciencemag.org/cgi/content/abstract/1132067v1?etocScience2007xxxx3165824593--59310.1126/science.1132067
ref77electronicIn situ DNA synthesis on glass substrate for microarray fabrication using self-focusing acoustic transducersynthetic biologyhttp://ieeexplore.ieee.org/search/srchabstract.jsp?arnumber=1613915&isnumber=33881&punumber=8856&k2dockey=1613915@ieeejrns&query=(+eun+sok+kim%3Cin%3Eau)&pos=3A proof of concept of using SFATs (self-focusing acoustic transducers) to print DNA oligos.
Chan2005articleRefactoring bacteriophage T7.refactoringhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16729053&query_hl=5&itool=pubmed_docsumChan, Leon ; Kosuri, Sriram ; Endy, DrewMolecular systems biology2005xxxx12005--001810.1038/msb4100025
Zhang2007articleMultimodal fast optical interrogation of neural circuitryNeurobiologyhttp://www.nature.com/nature/journal/v446/n7136/abs/nature05744.htmlZhang, Feng ; Wang, Li-Ping ; Brauner, Martin ; Liewald, Jana ; Kay, Kenneth ; Watzke, Natalie ; Wood, Phillip ; Bamberg, Ernst ; Nagel, Georg ; Gottschalk, Alexander ; Deisseroth, KarlNature2007Apr054467136633--63910.1038/nature05744
ref80electronicApplied Biodynamics Laboratory, Boston U.Labhttp://www.bu.edu/abl/Our lab is focused on developing and using nonlinear dynamics approaches to study, mimic and improve the function of biological systems. We are currently working in three areas:SB andsynrhetic biology
Andrianantoandro2006carticleSynthetic biology: new engineering rules for an emerging discipline.systems biologyhttp://www.nature.com/msb/journal/v2/n1/full/msb4100073.htmlAndrianantoandro, Ernesto ; Basu, Subhayu ; Karig, David ; Weiss, RonMolecular systems biology [electronic resource].2006xxxx22006--002810.1038/msb4100073
Heinemann2006articleSynthetic biology--putting engineering into biology.systems biologyhttp://dx.doi.org/10.1093/bioinformatics/btl469Heinemann, Matthias ; Panke, SvenBioinformatics (Oxford, England)2006Nov1522222790--279910.1093/bioinformatics/btl469
Drubin2007barticleDesigning biological systems.systems biologyhttp://www.genesdev.org/cgi/content/full/21/3/242Drubin, David ; Way, Jeffrey ; Silver, PamelaGenes \& development2007Feb01213242--25410.1101/gad.1507207
Sismour2005articleSynthetic biology.systems biologyhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16255644&query_hl=1&itool=pubmed_DocSumSismour, A. ; Benner, StevenExpert opinion on biological therapy2005Novxx5111409--141410.1517/14712598.5.11.1409
ref85electronicSpringerLink - Journal Articlesynthetic biologyhttp://www.springerlink.com/content/k7377586j4305247/
Yokobayashi2002aarticleFrom the Cover: Directed evolution of a genetic circuitsynthetic biologyhttp://www.pnas.org/cgi/content/abstract/99/26/16587?etocYokobayashi, Yohei ; Weiss, Ron ; Arnold, FrancesProceedings of the National Academy of Sciences2002Dec24992616587--1659110.1073/pnas.252535999
ref87articleGenetic parts to program bacteriasynthetic biologyhttp://dx.doi.org/10.1016/j.copbio.2006.09.001Current Opinion in Biotechnology2006xxxx175548--54810.1016/j.copbio.2006.09.001
ref88articleThe Generation of New Protein Functions by the Combination of Domainsstructureshttp://dx.doi.org/10.1016/j.str.2006.11.009Structure2007xxxx15185--8510.1016/j.str.2006.11.009
Sprinzak2005aarticleReconstruction of genetic circuitssynthetic biologyhttp://www.nature.com/nature/journal/v438/n7067/full/nature04335.htmlSprinzak, David ; Elowitz, MichaelNature2005Nov244387067443--44810.1038/nature04335
Hasty2001bookDesigner Gene Networks: Towards Fundamental Cellular Controlgenetic networkhttp://arxiv.org/abs/physics/0103034Hasty, Jeff ; Isaacs, Farren ; Dolnik, Milos ; McMillen, David ; Collins, J. J.2001Mar13
Fox2007articleImproving catalytic function by ProSAR-driven enzyme evolutiondirected evolutionhttp://www.nature.com/nbt/journal/vaop/ncurrent/abs/nbt1286.htmlFox, Richard ; Davis, S. ; Mundorff, Emily ; Newman, Lisa ; Gavrilovic, Vesna ; Ma, Steven ; Chung, Loleta ; Ching, Charlene ; Tam, Sarena ; Muley, Sheela ; Grate, John ; Gruber, John ; Whitman, John ; Sheldon, Roger ; Huisman, GjaltNat Biotech2007Feb18advanced online publication10.1038/nbt1286
ref92articleSynthetic biology projects in vitroCell-Free Systemhttp://www.genome.org/cgi/content/abstract/gr.5776007v1?papetocGenome Research2006xxxx1711--110.1101/gr.5776007
ref93articleGenome Biology | Full text | Fast, cheap and somewhat in controlsynthetic biologyhttp://dx.doi.org/10.1186/gb-2006-7-8-114Genome Biology2006xxxx78114--11410.1186/gb-2006-7-8-114
Thattai2004articleStochastic Gene Expression in Fluctuating Environmentsgene expressionhttp://www.genetics.org/cgi/content/abstract/167/1/523Thattai, Mukund ; Van Oudenaarden, AlexanderGenetics2004May011671523--53010.1534/genetics.167.1.523
Li2007articleHarnessing homologous recombination in vitro to generate recombinant DNA via SLICmethodhttp://www.nature.com/nmeth/journal/vaop/ncurrent/abs/nmeth1010.htmlLi, Mamie ; Elledge, StephenNat Meth2007Feb11advanced online publication10.1038/nmeth1010
ref96electronicETC Group - Publications - Extreme Genetic Engineering: An Introduction to Synthetic Biologytech talk 2-12-07http://www.etcgroup.org/en/materials/publications.html?id=602a contrary position on some synthetic bio issues. well worth checking out to be aware of the government and world-wide issues that may shape this field's future. (smolkelab 2007-02-12 16:56:43)* If a small circle of synthetic biologists get their way, governance of extreme genetic engineering will be left entirely in their hands. * There must be a broad societal debate on synthetic biology’s wider socio-economic and ethical implications, including potential impacts on health, environment, human rights and security. * It is not for scientists to either control public discourse or determine regulatory frameworks.
Shou2007aarticleFrom the Cover: Synthetic cooperation in engineered yeast populationstech talk 2-12-07http://www.pnas.org/cgi/content/abstract/0610575104v1Shou, Wenying ; Ram, Sri ; Vilar, JoseProceedings of the National Academy of Sciences2007Feb0610461877--188210.1073/pnas.0610575104Cooperative interactions are key to diverse biological phenomena ranging from multicellularity to mutualism. Such diversity makes the ability to create and control cooperation desirable for potential applications in areas as varied as agriculture, pollutant treatment, and medicine. Here we show that persistent cooperation can be engineered by introducing a small set of genetic modifications into previously noninteracting cell populations. Specifically, we report the construction of a synthetic obligatory cooperative system, termed CoSMO (cooperation that is synthetic and mutually obligatory), which consists of a pair of nonmating yeast strains, each supplying an essential metabolite to the other strain. The behavior of the two strains in isolation, however, revealed unintended constraints that restrict cooperation, such as asymmetry in starvation tolerance and delays in nutrient release until near cell death. However, the joint system is shown mathematically and experimentally to be viable over a wide range of initial conditions, with oscillating population ratio settling to a value predicted by nutrient supply and consumption. Unexpectedly, even in the absence of explicitly engineered mechanisms to stabilize cooperation, the cooperative system can consistently develop increased ability to survive reductions in population density. Extending synthetic biology from the design of genetic circuits to the engineering of ecological interactions, CoSMO provides a quantitative system for linking processes at the cellular level to the collective behavior at the system level, as well as a genetically tractable system for studying the evolution of cooperation.
Drubin2007carticleDesigning biological systemsreviewhttp://www.genesdev.org/cgi/content/full/21/3/242Drubin, David ; Way, Jeffrey ; Silver, PamelaGenes and Development2007Feb01213242--25410.1101/gad.1507207
ref99articleLight-powering Escherichia coli with proteorhodopsinenergyhttp://dx.doi.org/10.1073/pnas.0611035104Proceedings of the National Academy of Sciences2007xxxx10.1073/pnas.0611035104
Shou2007barticleSynthetic cooperation in engineered yeast populationsyeasthttp://www.pnas.org/cgi/content/abstract/0610575104v1Shou, Wenying ; Ram, Sri ; Vilar, J. M. G.Proceedings of the National Academy of Sciences2007Jan310610575104--061057510410.1073/pnas.0610575104
Lim2007articleA multistep epigenetic switch enables the stable inheritance of DNA methylation statessynthetic biologyhttp://www.nature.com/ng/journal/vaop/ncurrent/abs/ng1956.htmlLim, Han ; Van Oudenaarden, AlexanderNat Genet2007Febxx392269--27510.1038/ng1956
ref102articleSynthetic biology projects in vitrosynthetic biologyhttp://www.genome.org/cgi/content/abstract/gr.5776007v1?papetocGenome Research2006xxxx1711--110.1101/gr.5776007
ref103articleGenetic parts to program bacteriasynthetic biologyhttp://dx.doi.org/10.1016/j.copbio.2006.09.001Current Opinion in Biotechnology2006xxxx175548--54810.1016/j.copbio.2006.09.001
Simpson2006articleCell-free synthetic biology: a bottom-up approach to discovery by designCell-Free Systemhttp://www.nature.com/msb/journal/v2/n1/full/msb4100104.htmlSimpson, MichaelMol Syst Biol2006Dec12210.1038/msb4100104
Kim2006articleConstruction of an in vitro bistable circuit from synthetic transcriptional switchessynthetic biologyhttp://www.nature.com/msb/journal/v2/n1/full/msb4100099.htmlKim, Jongmin ; White, Kristin ; Winfree, ErikMol Syst Biol2006Dec12210.1038/msb4100099
ref106articleA synthetic multicellular system for programmed pattern formationsynthetic biologyhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15858574Nature2005xxxx43470371130--113010.1038/nature03461
ref107articleCellular Logic with Orthogonal Ribosomessynthetic biologyhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16351070&query_hl=8&itool=pubmed_docsumJournal of the American Chemical Society2005xxxx1275017584--1758410.1021/ja055338d
Hasty2002articleEngineered gene circuitsgenetic networkhttp://www.nature.com/nature/journal/v420/n6912/full/nature01257.htmlHasty, Jeff ; McMillen, David ; Collins, J.Nature2002Nov144206912224--23010.1038/nature01257
ref109electronicZinc Fingers Consortiumgenetic networkhttp://www.zincfingers.org/scientific-background.htm
ref110articleStandardized reagents and protocols for engineering zinc finger nucleases by modular assemblygenetic networkhttp://www.nature.com/nprot/journal/v1/n3/full/nprot.2006.259.htmlNature Protocols2006xxxx141637--163710.1038/nprot.2006.259
ref111articleSynthetic biology--putting engineering into biologysynthetic biologyhttp://dx.doi.org/10.1093/bioinformatics/btl469Bioinformatics2006xxxx22222790--279010.1093/bioinformatics/btl469
Seelig2006articleEnzyme-Free Nucleic Acid Logic Circuitsgenetic networkhttp://www.sciencemag.org/cgi/content/full/314/5805/1585Seelig, Georg ; Soloveichik, David ; Zhang, David ; Winfree, ErikScience2006Dec0831458051585--158810.1126/science.1132493
Forster2006aarticleSynthetic biology projects in vitrosynthetic biologyhttp://www.genome.org/cgi/content/abstract/gr.5776007v1?papetocForster, Anthony ; Church, GeorgeGenome Research2006Dec065776007--577600710.1101/gr.5776007
Atsumi2006articleA synthetic phage \{lambda\} regulatory circuitsynthetic biologyhttp://www.pnas.org/cgi/content/abstract/0603052103v1?etocAtsumi, Shota ; Little, JohnProceedings of the National Academy of Sciences2006Nov290603052103--060305210310.1073/pnas.0603052103
ref115electronicThe New Atlantis - The Promise and Perils of Synthetic Biology - Jonathan B. Tucker and Raymond A. Zilinskassynthetic biologyhttp://www.thenewatlantis.com/archive/12/tuckerzilinskas.htm
ref116electronicOptimizing Biological Circuits: Integrating Rational Design with Directed Evolutionsynthetic biologyhttp://aiche.confex.com/aiche/2006/preliminaryprogram/abstract_52714.htm
Collins2005articleDirected evolution of Vibrio fischeri LuxR for increased sensitivity to a broad spectrum of acyl-homoserine lactonessynthetic biologyhttp://www.blackwell-synergy.com/links/doi/10.1111/j.1365-2958.2004.04437.x/enhancedabs/Collins, Cynthia ; Arnold, Frances ; Leadbetter, JaredMolecular Microbiology2005xxxx553712--72310.1111/j.1365-2958.2004.04437.x
Vilar2006articleModularizing gene regulationgene expressionhttp://www.nature.com/msb/journal/v2/n1/full/msb4100058.htmlVilar, JoseMol Syst Biol2006Mar21210.1038/msb4100058
Wolf2003articleMotifs, modules and games in bacteria.synthetic biologyhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12732301&dopt=AbstractWolf, Denise ; Arkin, AdamCurrent opinion in microbiology.2003Aprxx62125--134
Michnick2006articleA luxRury of synthetic signalspLuxRhttp://www.nature.com/nbt/journal/v24/n6/full/nbt0606-658.htmlMichnick, StephenNat Biotech2006Junxx246658--66010.1038/nbt0606-658
Cookson2005articleMonitoring dynamics of single-cell gene expression over multiple cell cyclesthesis\_chapter\_2http://www.nature.com/msb/journal/v1/n1/full/msb4100032.htmlCookson, Scott ; Ostroff, Natalie ; Pang, Wyming ; Volfson, Dmitri ; Hasty, AndMol Syst Biol2005Nov22114100032--410003110.1038/msb4100032
Anderson2006articleEnvironmentally controlled invasion of cancer cells by engineered bacteria.synthetic biologyhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16330045&dopt=CitationAnderson, J. ; Clarke, Elizabeth ; Arkin, Adam ; Voigt, ChristopherJournal of molecular biology.2006Jan273554619--62710.1016/j.jmb.2005.10.076
ref123electronicTuning genetic control through promoter engineering -- Alper et al. 102 (36): 12678 -- Proceedings of the National Academy of Sciencessynthetic biologyhttp://www.pnas.org/cgi/content/abstract/102/36/12678
Schibler2005articleCellular oscillators: rhythmic gene expression and metabolism.synthetic biologyhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15780601&dopt=CitationSchibler, Ueli ; Naef, FelixCurrent opinion in cell biology.2005Aprxx172223--22910.1016/j.ceb.2005.01.007
Atsumi2004articleRegulatory circuit design and evolution using phage \{lambda\}synthetic biologyhttp://www.genesdev.org/cgi/content/abstract/18/17/2086Atsumi, Shota ; Little, JohnGenes and Development2004Sep0118172086--209410.1101/gad.1226004
Balagadde2005articleLong-Term Monitoring of Bacteria Undergoing Programmed Population Control in a Microchemostatsynthetic biologyhttp://www.sciencemag.org/cgi/content/abstract/309/5731/137Balagadde, Frederick ; You, Lingchong ; Hansen, Carl ; Arnold, Frances ; Quake, StephenScience2005Jul013095731137--14010.1126/science.1109173
ref127electronicThe Device Physics of Cellular Logic Gates - Weiss, Basu (ResearchIndex)synthetic biologyhttp://citeseer.ist.psu.edu/weiss02device.html
Ehrenberg2003articleSystems Biology Is Taking Offthesis\_chapter\_1http://www.genome.org/cgi/content/full/13/11/2377Ehrenberg, Mans ; Elf, Johan ; Aurell, Erik ; Sandberg, Rickard ; Tegner, AndGenome Research2003Nov0113112377--2380
Hooshangi2005barticleUltrasensitivity and noise propagation in a synthetic transcriptional cascadethesis\_chapter\_2http://dx.doi.org/10.1073/pnas.0408507102Hooshangi, Sara ; Thiberge, Stephan ; Weiss, AndProceedings of the National Academy of Sciences2005Mar08102103581--358610.1073/pnas.0408507102
Bulter2004articleFrom the Cover: Design of artificial cell-cell communication using gene and metabolic networkssynthetic biologyhttp://www.pnas.org/cgi/content/abstract/pnas;101/8/2299Bulter, Thomas ; Lee, Sun-Gu ; Wong, Wilson ; Fung, Eileen ; Connor, Michael ; Liao, JamesProceedings of the National Academy of Sciences2004Feb2410182299--230410.1073/pnas.0306484101
You2004articleProgrammed population control by cell-cell communication and regulated killingthesis\_chapter\_1http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15064770You, Lingchong ; Sidney-Cox, Robert ; Weiss, Ron ; Arnold, AndNature2004Apr224286985868--87110.1038/nature02491
Weiss2003articleGenetic circuit building blocks for cellular computation, communications, and signal processingthesis\_chapter\_1http://dx.doi.org/10.1023/a:1023307812034Weiss, Ron ; Basu, Subhayu ; Hooshangi, Sara ; Kalmbach, Abigail ; Karig, David ; Mehreja, Rishabh ; Netravali, IlkaNatural Computing2003xxxx2147--4710.1023/a:1023307812034
McAdams2000articleTowards a circuit engineering discipline.synthetic biologyhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10801411&dopt=AbstractMcAdams, H. H. ; Arkin, A.Current biology : CB.2000Apr20108318--320
McMillen2002articleSynchronizing genetic relaxation oscillators by intercell signalingapplicationhttp://www.pnas.org/cgi/content/abstract/99/2/679McMillen, David ; Kopell, Nancy ; Hasty, Jeff ; Collins, J. J.Proceedings of the National Academy of Sciences2002Jan22992679--68410.1073/pnas.022642299
Kobayashi2004articleProgrammable cells: Interfacing natural and engineered gene networkscell-cell signalinghttp://www.pnas.org/cgi/content/abstract/101/22/8414?etocKobayashi, Hideki ; Kaern, Mads ; Araki, Michihiro ; Chung, Kristy ; Gardner, Timothy ; Cantor, Charles ; Collins, JamesProceedings of the National Academy of Sciences2004Jun01101228414--841910.1073/pnas.0402940101
Tegner2003articleReverse engineering gene networks: Integrating genetic perturbations with dynamical modelingsynthetic biologyhttp://www.pnas.org/cgi/content/full/100/10/5944?ijkey=8ceb79f77cfcaade8d7b71bbdafdd0e60853460e&keytype2=tf_ipsecshaTegner, Jesper ; Yeung, M. K. ; Hasty, Jeff ; Collins, JamesProceedings of the National Academy of Sciences2003May13100105944--594910.1073/pnas.0933416100
Alm2003articleBiological networks.synthetic biologyhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=12727512&dopt=CitationAlm, Eric ; Arkin, AdamCurrent opinion in structural biology.2003Aprxx132193--202
Isaacs2003articlePrediction and measurement of an autoregulatory genetic modulethesis\_chapter\_2http://www.pnas.org/cgi/content/abstract/100/13/7714Isaacs, Farren ; Hasty, Jeff ; Cantor, Charles ; Collins, J. J.Proceedings of the National Academy of Sciences2003Jun24100137714--771910.1073/pnas.1332628100
Yokobayashi2002barticleDirected evolution of a genetic circuitsynthetic biologyhttp://www.pnas.org/cgi/content/abstract/99/26/16587?etocYokobayashi, Yohei ; Weiss, Ron ; Arnold, FrancesProceedings of the National Academy of Sciences2002Dec24992616587--1659110.1073/pnas.252535999
ref140bookTowards Biological System Identification: Fast and Accurate Estimatessynthetic biologyhttp://www.its.caltech.edu/~mjdunlop/papers/CDC06-draft.pdfDunlop, Mary ; Murray, Richard
Pottage2006articleToo Much Ownership: Bio-prospecting in the Age of Synthetic Biologysynthetic biologyhttp://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=446754Pottage, AlainBioSocieties. Cambridge University Press2006Junxx137--15810.1017/S1745855206050241
Swain2006articleNoise in genetic and neural networkssynthetic biologyhttp://link.aip.org/link/?CHA/16/026101/1Swain, Peter ; Longtin, AndreChaos: An Interdisciplinary Journal of Nonlinear Science2006xxxx162026101--026101
McDaniel2005articleAdvances in synthetic biology: on the path from prototypes to applications.thesis\_chapter\_1http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16019200McDaniel, Ryan ; Weiss, RonCurrent opinion in biotechnology.2005Augxx164476--48310.1016/j.copbio.2005.07.002
ref144articleEngineering Bacteria for Drug Productionsynthetic biologyhttp://www.nae.edu/nae/naefoe.nsf/0754c87f163f599e85256cca00588f49/85256dad0044ef2a852570bd00521b49/$FILE/Keasling.pdfKeasling, JayEngineering Bacteria for Drug Production
Blake2004articleSynthetic biology evolves.synthetic biologyhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15245901&dopt=CitationBlake, William ; Isaacs, FarrenTrends in biotechnology.2004Julxx227321--32410.1016/j.tibtech.2004.04.008
Ray2003articleAn evolutionary approach to synthetic biology: zen in the art of creating lifesynthetic biologyhttp://portal.acm.org/citation.cfm?id=903758.903778Ray, ThomasAdvances in evolutionary computing: theory and applications2003xxxx479--517
Pfleger2006aarticleCombinatorial engineering of intergenic regions in operons tunes expression of multiple genessynthetic biologyhttp://www.nature.com/nbt/journal/vaop/ncurrent/abs/nbt1226.htmlPfleger, Brian ; Pitera, Douglas ; Smolke, Christina ; Keasling, AndNat Biotech2006Augxx2481027--103210.1038/nbt1226
Check2005articleSynthetic biology: Designs on lifesynthetic biologyhttp://www.nature.com/nature/journal/v438/n7067/full/438417a.htmlCheck, ErikaNature2005Nov244387067417--41810.1038/438417a
Andrianantoandro2006darticleSynthetic biology: new engineering rules for an emerging disciplinesynthetic biologyhttp://www.nature.com/msb/journal/v2/n1/full/msb4100073.htmlAndrianantoandro, Ernesto ; Basu, Subhayu ; Karig, David ; Weiss, AndMol Syst Biol2006xxxx24100073--410007110.1038/msb4100073
Endy2005aarticleFoundations for engineering biologysynthetic biologyhttp://www.nature.com/nature/journal/v438/n7067/full/nature04342.htmlEndy, DrewNature2005Nov244387067449--45310.1038/nature04342
Ball2004articleSynthetic biology: Starting from scratchsynthetic biologyhttp://www.nature.com/nature/journal/v431/n7009/full/431624a.htmlBall, PhilipNature2004Oct074317009624--62610.1038/431624a
Elowitz2000aarticleA synthetic oscillatory network of transcriptional regulatorssynthetic biologyhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10659856&query_hl=7Elowitz, Michael ; Leibler, StanislasNature2000Jan204036767335--33810.1038/35002125
Brent2004articleA partnership between biology and engineeringthesis\_chapter\_1http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15470452Brent, RogerNat Biotech2004Octxx22101211--121410.1038/nbt1004-1211
Isaacs2006articleRNA synthetic biologyriboswitchhttp://dx.doi.org/10.1038/nbt1208Isaacs, Farren ; Dwyer, Daniel ; Collins, AndNat Biotech2006Mayxx245545--55410.1038/nbt1208
Fu2006aarticleA perspective of synthetic biology: assembling building blocks for novel functions.reviewhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16892318&itool=pubmed_DocSumFu, PengchengBiotechnology journal.2006Junxx16690--69910.1002/biot.200600019
Benner2005articleSynthetic biology.reviewhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15995697Benner, Steven ; Sismour, A.Nature reviews. Genetics.2005Julxx67533--54310.1038/nrg1637
ref157articleSynthetic biology--putting engineering into biologyreviewhttp://dx.doi.org/10.1093/bioinformatics/btl469Bioinformatics2006xxxx22222790--279010.1093/bioinformatics/btl469
Gardner2000articleConstruction of a genetic toggle switch in Escherichia coli.togglehttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10659857&query_hl=9Gardner, T. S. ; Cantor, C. R. ; Collins, J. J.Nature.2000Jan204036767339--34210.1038/350021310028-0836
Chin2006aarticleProgramming and engineering biological networks.genetichttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16842994&itool=pubmed_DocSumChin, Jason W.Current opinion in structural biology.2006Augxx164551--55610.1016/j.sbi.2006.06.0110959-440X
Krinke1990articleThe cleavage specificity of RNase III.synthetic biologyhttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=331951&tools=botKrinke, L. ; Wulff, D. L.Nucleic Acids Research1990Aug2518164809--48150305-1048
Smolke2002articleEffect of gene location, mRNA secondary structures, and RNase sites on expression of two genes in an engineered operonsynthetic biologyhttp://www3.interscience.wiley.com/cgi-bin/abstract/99019005/ABSTRACT?CRETRY=1&SRETRY=0Smolke, Christina D. ; Keasling, Jay D.Biotechnology and Bioengineering2002xxxx807762--77610.1002/bit.10434
Nilsson1984articleGrowth-rate dependent regulation of mRNA stability in Escherichia colimRNA degredationhttp://www.nature.com/nature/journal/v312/n5989/abs/312075a0.htmlNilsson, G. ; Belasco, J. ; Cohen, S. ; von Gabain, A.Nature1984Nov01312598975--7710.1038/312075a0
ref163electronicLibrary of Synthetic 5' Secondary Structures To Manipulate mRNA Stability in Escherichia colisynthetic biologyhttp://pubs.acs.org/cgi-bin/abstract.cgi/bipret/1999/15/i01/abs/bp9801143.html
Arraiano2003articlePost-transcriptional control of gene expression: effectors of mRNA decaysynthetic biologyhttp://www.blackwell-synergy.com/links/doi/10.1046/j.1365-2958.2003.03545.xArraiano, Cecilia Maria ; Maquat, Lynne ElizabethMolecular Microbiology2003xxxx491267--27610.1046/j.1365-2958.2003.03545.xDescription of various mechanisms of mRNA degredation
ref165electronicA comprehensive library of fluorescent transcriptional reporters for Escherichia colisynthetic biologyhttp://www.weizmann.ac.il/mcb/UriAlon/Papers/Zaslaver_Ecoli_library.pdf
ref166electronicSynthetic biology | Life 2.0 | Economist.comsynthetic biologyhttp://www.economist.com/business/displaystory.cfm?story_id=7854314
ref167electronicSynthetic Biologysynthetic biologyhttp://syntheticbiology.org/
Maeda2006aarticleRegulatory dynamics of synthetic gene networks with positive feedback.synthetic biologyhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16701695&query_hl=12&itool=pubmed_docsumMaeda, Yusuke T. ; Sano, MasakiJournal of molecular biology.2006Jun1635941107--112410.1016/j.jmb.2006.03.0640022-2836
ref169electronicCell -- Banaszynski et al.synthetic biologyhttp://www.cell.com/content/article/fulltext?uid=PIIS0092867406010130
ref170electronicSynthetic biology | Playing demigods | Economist.comsynthetic biologyhttp://www.economist.com/opinion/displaystory.cfm?story_id=E1_SRVQSST
ref171electronicSynthetic biology | Life 2.0 | Economist.comsynthetic biologyhttp://www.economist.com/business/displaystory.cfm?story_id=7854314
Church2005aarticleFrom systems biology to synthetic biologysynthetic biologyhttp://www.nature.com/msb/journal/v1/n1/full/msb4100007.html#b5Church, GeorgeMol Syst Biol2005Mar2911--110.1038/msb4100007
Forster2006barticleTowards synthesis of a minimal cellsynthetic biologyhttp://www.nature.com/msb/journal/v2/n1/full/msb4100090.htmlForster, Anthony ; Church, GeorgeMol Syst Biol2006Aug22210.1038/msb4100090
Forster2006carticleTowards synthesis of a minimal cellsynthetic biologyhttp://www.nature.com/msb/journal/v2/n1/full/msb4100090.htmlForster, Anthony ; Church, GeorgeMol Syst Biol2006Aug22210.1038/msb4100090
Lim2006articleModel-Based Design of Growth-Attenuated Virusessystems biologyhttp://compbiol.plosjournals.org/perlserv/?request=get-document&doi=10.1371%2Fjournal.pcbi.0020116Lim, Kwang-il ; Lang, Tobias ; Lam, Vy ; Yin, JohnPLoS Computational Biology2006Sep0129e11610.1371/journal.pcbi.0020116
ref176electronicSynthetic biology | Bedroom biotech | Economist.comsynthetic biologyhttp://www.economist.com/displayStory.cfm?Story_id=7854327Like information technology before it, biotech is starting to spawn hackers
ref177electronicSynthetic biology | Life 2.0 | Economist.comsynthetic biologyhttp://www.economist.com/displayStory.cfm?Story_id=7854314The new science of synthetic biology is poised between hype and hope. But its time will soon come. Describes this vein of science being on an innovation curve quite similar to Moore's law. Discusses BioBricks and work by Rob Carlson.
ref178electronicSynthetic biology | Playing demigods | Economist.comethicshttp://www.economist.com/research/articlesBySubject/displayStory.cfm?story_id=7854771&subjectid=526354Discusses innovation, possibilities and fears of synthetic biology. Recommends caution and monitoring, but not shut down.
Fu2006barticleA perspective of synthetic biology: Assembling building blocks for novel functions.synthetic biologyhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16892318&itool=pubmed_DocSumFu, PengchengBiotechnology journal.2006Junxx16690--69910.1002/biot.2006000191860-6768
Maeda2006barticleRegulatory dynamics of synthetic gene networks with positive feedback.synthetic biologyhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16701695&query_hl=12&itool=pubmed_docsumMaeda, Yusuke T. ; Sano, MasakiJournal of molecular biology.2006Jun1635941107--112410.1016/j.jmb.2006.03.0640022-2836
Chin2006barticleProgramming and engineering biological networks.genehttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16842994&itool=pubmed_DocSumChin, Jason W.Current opinion in structural biology.2006Augxx164551--55610.1016/j.sbi.2006.06.0110959-440X
Pfleger2006barticleCombinatorial engineering of intergenic regions in operons tunes expression of multiple genessynthetic biologyhttp://www.nature.com/nbt/journal/vaop/ncurrent/abs/nbt1226.htmlPfleger, Brian ; Pitera, Douglas ; Smolke, Christina ; Keasling, JayNature Biotechnology2006Jul16advanced online publication81027--103210.1038/nbt122610870156
Pfleger2006carticleCombinatorial engineering of intergenic regions in operons tunes expression of multiple genessynthetic biologyhttp://www.nature.com/nbt/journal/vaop/ncurrent/abs/nbt1226.htmlPfleger, Brian ; Pitera, Douglas ; Smolke, Christina ; Keasling, JayNature Biotechnology2006Jul16advanced online publication81027--103210.1038/nbt122610870156
Posfai2006articleEmergent Properties of Reduced-Genome Escherichia coliemergencehttp://www.sciencemag.org/cgi/content/abstract/312/5776/1044?etocPosfai, Gyorgy ; Plunkett, Guy III ; Feher, Tamas ; Frisch, David ; Keil, Gunther M. ; Umenhoffer, Kinga ; Kolisnychenko, Vitaliy ; Stahl, Buffy ; Sharma, Shamik S. ; de Arruda, Monika ; Burland, Valerie ; Harcum, Sarah W. ; Blattner, Frederick R.Science2006May1931257761044--1046
Villalobos2006articleGene Designer: A Synthetic Biology Tool for Constructing Artificial DNA Segments.synthetic biologyhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16756672&itool=pubmed_DocSumVillalobos, Alan ; Ness, Jon ; Gustafsson, Claes ; Minshull, Jeremy ; Govindarajan, SridharBMC Bioinformatics2006Jun067128510.1186/1471-2105-7-2851471-2105
Andrianantoandro2006earticleSynthetic biology: new engineering rules for an emerging discipline.synthetic biologyhttp://www.nature.com/msb/journal/v2/n1/full/msb4100073.htmlAndrianantoandro, Ernesto ; Basu, Subhayu ; Karig, David ; Weiss, RonMolecular systems biology [electronic resource].2006xxxx2msb4100073--002810.1038/msb41000731744-4292
Xiang2006articleShort hairpin RNA-expressing bacteria elicit RNA interference in mammalssynthetic biologyhttp://www.nature.com/nbt/journal/vaop/ncurrent/abs/nbt1211.htmlXiang, Shuanglin ; Fruehauf, Johannes ; Li, ChiangNature Biotechnology2006May14advanced online publication6697--70210.1038/nbt1211Nonpathogenic Escherichia coli were engineered to transcribe shRNAs from a plasmid containing the invasin gene Inv and the listeriolysin O gene HlyA, which encode two bacterial factors needed for successful transfer of the shRNAs into mammalian cells.10870156
ref188articleComputational redesign of endonuclease DNA binding and cleavage specificityProteinhttp://www.nature.com/nature/journal/v441/n7093/full/nature04818.htmlNature2006xxxx4417093656--65610.1038/nature04818
Church2005barticleFrom systems biology to synthetic biologysynthetic biologyhttp://www.nature.com/msb/journal/v1/n1/full/msb4100007.html#b5Church, GeorgeMolecular systems biology [electronic resource].2005Mar2911msb4100007--003210.1038/msb4100007editorial1744-4292
ref190electronicSynthetic Biologysynthetic biologyhttp://syntheticbiology.org/
Endy2005barticleFoundations for engineering biologysynthetic biologyhttp://www.nature.com/nature/journal/v438/n7067/full/nature04342.htmlEndy, DrewNature2005Nov244387067449--45310.1038/nature043420028-0836
ref192electronicOpenWetWaresynthetic biologyhttp://openwetware.org/wiki/Main_Pagesee the comic Adventures in synthetic biology
ref193electronicComic 1 : Adventures in Synthetic Biology : Naturesynthetic biologyhttp://www.nature.com/nature/comics/syntheticbiologycomic/index.html
Benner2003articleSynthetic biology: Act naturalnature conceptshttp://www.nature.com/nature/journal/v421/n6919/full/421118a.htmlBenner, StevenNature2003Jan09421691911810.1038/421118a0028-0836
ref195electronicEngineering Life: Building a Fab for Biology -- [ BIOTECHNOLOGY ] -- Principles and practices learned from engineering successes can help transform biotechnology from a specialized craft into a mature industrysynthetic biologyhttp://www.sciam.com/article.cfm?chanID=sa006&colID=1&articleID=000E491E-B2F9-146C-B2F983414B7F0000By the Bio FAB group (ht265 2006-06-06 13:24:51)Synthetic Biology by Baker
ref196electronicSynthetic biologists try to calm fearssynthetic biologyhttp://www.nature.com/news/2006/060522/full/441388a.html
Morton2006aarticleSynthetic Biology 2.0: More bloggerssynthetic biologyhttp://mainlymartian.blogs.com/semijournal/2006/05/synthetic_biolo_6.htmlMorton, OliverMainlyMartian2006May23
ref198articleDomains, Motifs, and Scaffolds: The Role of Modular Interactions in the Evolution and Wiring of Cell Signaling Circuitssynthetic biologyhttp://dx.doi.org/10.1146/annurev.biochem.75.103004.142710Annual review of biochemistry.2005xxxx75060407064831004--68010.1146/annurev.biochem.75.103004.1427100066-4154
Chin2006carticleModular approaches to expanding the functions of living mattersynthetic biologyhttp://www.nature.com/nchembio/journal/v2/n6/abs/nchembio789.htmlChin, JasonNature chemical biology.2006Junxx26304--31110.1038/nchembio7891552-4450
Morton2006barticleSynthetic Biology 2.0: Medicine (and its malcontents?)synthetic biologyhttp://mainlymartian.blogs.com/semijournal/2006/05/synthetic_biolo_5.htmlMorton, OliverMainlyMartian2006May22
Morton2006carticleSynthetic Biology 2.0: Also blogging the meeting...synthetic biologyhttp://mainlymartian.blogs.com/semijournal/2006/05/syhtetic_biolog.htmlMorton, OliverMainlyMartian2006May21
Morton2006darticleSynthetic Biology 2.0: Opposing viewssynthetic biologyhttp://mainlymartian.blogs.com/semijournal/2006/05/synthetic_biolo_3.htmlMorton, OliverMainlyMartian2006May20
Morton2006earticleSynthetic Biology 2.0: Fun to comesynthetic biologyhttp://mainlymartian.blogs.com/semijournal/2006/05/synthetic_biolo_2.htmlMorton, OliverMainlyMartian2006May20
Morton2006farticleSynthetic Biology 2.0: BTUs per bushelsynthetic biologyhttp://mainlymartian.blogs.com/semijournal/2006/05/synthetic_biolo_1.htmlMorton, OliverMainlyMartian2006May20
Morton2006garticleSynthetic Biology 2.0: What's afoot?synthetic biologyhttp://mainlymartian.blogs.com/semijournal/2006/05/synthetic_biolo.htmlMorton, OliverMainlyMartian2006May20
Andrianantoandro2006farticleSynthetic biology: new engineering rules for an emerging disciplinesynthetic biologyhttp://www.nature.com/msb/journal/v2/n1/full/msb4100073.htmlAndrianantoandro, Ernesto ; Basu, Subhayu ; Karig, David ; Weiss, RonMolecular systems biology [electronic resource].2006xxxx2msb4100073--002810.1038/msb41000731744-4292
Endy2005carticleFoundations for engineering biologyfunhttp://www.nature.com/nature/journal/v438/n7067/full/nature04342.htmlEndy, DrewNature2005Nov244387067449--45310.1038/nature043420028-0836
Elowitz2000barticleA synthetic oscillatory network of transcriptional regulators.synthetic biologyhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10659856&query_hl=7Elowitz, M. B. ; Leibler, S.Nature.2000Jan204036767335--33810.1038/350021250028-0836
Guet2002aarticleCombinatorial synthesis of genetic networks.synthetic biologyhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12029133&query_hl=7Guet, Călin C. ; Elowitz, Michael B. ; Hsing, Weihong ; Leibler, StanislasScience.2002May2429655721466--147010.1126/science.10674071095-9203
Levskaya2005aarticleSynthetic biology: Engineering Escherichia coli to see lightsynthetic biologyhttp://www.nature.com/nature/journal/v438/n7067/abs/nature04405.htmlLevskaya, Anselm ; Chevalier, Aaron ; Tabor, Jeffrey ; Simpson, Zachary Booth ; Lavery, Laura ; Levy, Matthew ; Davidson, Eric ; Scouras, Alexander ; Ellington, Andrew ; Marcotte, Edward ; Voigt, ChristopherNature.2005Nov244387067441--44210.1038/nature044051476-4687
Bray1995articleProtein molecules as computational elements in living cellssynthetic biologyhttp://www.nature.com/nature/journal/v376/n6538/abs/376307a0.htmlBray, DennisNature.1995Jul273766538307--31210.1038/376307a00028-0836
Pawson1995articleProtein modules and signalling networkssynthetic biologyhttp://www.nature.com/nature/journal/v373/n6515/abs/373573a0.htmlPawson, TonyNature1995Feb163736515573--58010.1038/373573a0
ref213articleBioMed Central | Abstract | 1471-2105-7-55 | PathSys: integrating molecular interaction graphs for systems biologysynthetic biologyhttp://dx.doi.org/10.1186/1471-2105-7-55BMC Bioinformatics2006Feb07715510.1186/1471-2105-7-5514712105
ref214electronicSynthetic Biology in Practicesynthetic biologyhttp://blog.lib.umn.edu/sali0090/synbio/
ref215electronicGeneral Review Papers - IGEMsynthetic biologyhttp://parts.mit.edu/wiki/index.php/General_Review_Papers
ref216electronicSynthetic systems biologysynthetic biologyhttp://www.ncbs.res.in/~faculty/ssb/apply1.html
Boonyarattanakalin2006articleSynthesis of an Artificial Cell Surface Receptor that Enables Oligohistidine Affinity Tags to Function as Metal-Dependent Cell-Penetrating Peptides.synthetic biologyhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16402806&query_hl=1&itool=pubmed_docsumBoonyarattanakalin, Siwarutt ; Athavankar, Sonalee ; Sun, Qi ; Peterson, Blake R.Journal of the American Chemical Society.2006Jan181282386--38710.1021/ja056126j0002-7863
Rackham2005articleA network of orthogonal ribosome x mRNA pairs.synthetic biologyhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16408021&query_hl=1&itool=pubmed_docsumRackham, Oliver ; Chin, Jason W.Nature chemical biology.2005Augxx13159--16610.1038/nchembio7191552-4450
Volgraf2006articleAllosteric control of an ionotropic glutamate receptor with an optical switch.synthetic biologyhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16408092&query_hl=1&itool=pubmed_docsumVolgraf, Matthew ; Gorostiza, Pau ; Numano, Rika ; Kramer, Richard H. ; Isacoff, Ehud Y. ; Trauner, DirkNature chemical biology.2006Janxx2147--5210.1038/nchembio7561552-4450
Simpson2004aarticleRewiring the cell: synthetic biology moves towards higher functional complexity.synthetic biologyhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15491797&query_hl=4Simpson, Michael L.Trends Biotechnol2004Novxx2211555--55710.1016/j.tibtech.2004.09.0030167-7799
ref221electronicResearch Papers in Synthetic Biology - IGEMsynthetic biologyhttp://parts.mit.edu/wiki/index.php/Research_Papers_in_Synthetic_Biology
ref222electronicRegistry of Standard Biological Partssynthetic biologyhttp://parts.mit.edu/
ref223electronicMain Page - IGEMsynthetic biologyhttp://parts.mit.edu/wiki/index.php/Main_Page
ref224electronicSignOnSanDiego.com > News > Science -- Command performancessynthetic biologyhttp://www.signonsandiego.com/news/science/20051214-9999-lz1c14circuit.html#``Controlling organisms with biological circuits, opens up a world of possibilities and dangers''
Chen2005aarticleArtificial cell-cell communication in yeast Saccharomyces cerevisiae using signaling elements from Arabidopsis thalianasynthetic biologyhttp://www.nature.com/nbt/journal/vaop/ncurrent/full/nbt1162.htmlChen, Ming-Tang ; Weiss, RonNature biotechnology.2005Nov20advanced online publication121551--155510.1038/nbt11621087-0156
Fung2005articleA synthetic gene-metabolic oscillatorsynthetic biologyhttp://www.nature.com/nature/journal/v435/n7038/abs/nature03508.htmlFung, Eileen ; Wong, Wilson ; Suen, Jason ; Bulter, Thomas ; Lee, Sun-gu ; Liao, JamesNature2005May054357038118--12210.1038/nature035080028-0836
Endy2005darticleFoundations for engineering biologysynthetic biologyhttp://www.nature.com/nature/journal/v438/n7067/full/nature04342.htmlEndy, DrewNature2005Nov244387067449--45310.1038/nature04342Engineered biological systems have been used to manipulate information, construct materials, process chemicals, produce energy, provide food, and help maintain or enhance human health and our environment. Unfortunately, our ability to quickly and reliably engineer biological systems that behave as expected remains quite limited. Foundational technologies that make routine the engineering of biology are needed. Vibrant, open research communities and strategic leadership are necessary to ensure that the development and application of biological technologies remains overwhelmingly constructive.0028-0836
Levskaya2005barticleSynthetic biology: Engineering Escherichia coli to see lightsynthetic biologyhttp://www.nature.com/nature/journal/v438/n7067/abs/nature04405.htmlLevskaya, Anselm ; Chevalier, Aaron ; Tabor, Jeffrey ; Simpson, Zachary Booth ; Lavery, Laura ; Levy, Matthew ; Davidson, Eric ; Scouras, Alexander ; Ellington, Andrew ; Marcotte, Edward ; Voigt, ChristopherNature.2005Nov244387067441--44210.1038/nature044051476-4687
Endy2005earticleFoundations for engineering biologysynthetic biologyhttp://www.nature.com/nature/journal/v438/n7067/full/nature04342.htmlEndy, DrewNature2005Nov244387067449--45310.1038/nature043420028-0836
Sprinzak2005barticleReconstruction of genetic circuitssynthetic biologyhttp://www.nature.com/nature/journal/v438/n7067/full/nature04335.htmlSprinzak, David ; Elowitz, MichaelNature2005Nov244387067443--44810.1038/nature043350028-0836
Levskaya2005carticleSynthetic biology: Engineering Escherichia coli to see light - article in NaturePhotographyhttp://www.nature.com/nature/journal/v438/n7067/abs/nature04405.htmlLevskaya, Anselm ; Chevalier, Aaron ; Tabor, Jeffrey ; Simpson, Zachary Booth ; Lavery, Laura ; Levy, Matthew ; Davidson, Eric ; Scouras, Alexander ; Ellington, Andrew ; Marcotte, Edward ; Voigt, ChristopherNature.2005Nov244387067441--44210.1038/nature04405We have designed a bacterial system that is switched between different states by red light. The system consists of a synthetic sensor kinase that allows a lawn of bacteria to function as a biological film, such that the projection of a pattern of light on to the bacteria produces a high-definition (about 100 megapixels per square inch), two-dimensional chemical image. This spatial control of bacterial gene expression could be used to 'print' complex biological materials, for example, and to investigate signalling pathways through precise spatial and temporal control of their phosphorylation steps.1476-4687
ref232electronicBacterial film : NaturePhotographyhttp://www.nature.com/nature/journal/v438/n7067/edsumm/e051124-07.htmlPhytochromes are membrane-bound photoreceptors found in plants and some bacteria. There are none in Escherichia coli, but with the introduction of a genetic circuit that fuses a cyanobacterial photoreceptor to an intracellular kinase, E. coli sees the light. The bacteria then act as a photographic film, producing a chemical image when light is projected onto it.
ref233electronicGuardian Unlimited || Super-sensitive film made from living bacteria - on article in NaturePhotographyhttp://www.guardian.co.uk/science/story/0,3605,1649439,00.htmlScientists have created a new kind of photographic film, made from living bacteria, which is able to detect nano-scale features and print ultra-detailed images. By genetically engineering a common form of bacterium they were able to make it switch its pigment production on and off in response to a light.
ref234electronicFoundations for engineering biologysynthetic biologyhttp://www.nature.com/nature/journal/v438/n7067/pdf/nature04342.pdf
ref235electronicBacteria can take pictures of themselves - Boston.com - on article in Naturesynthetic biologyhttp://www.boston.com/news/science/articles/2005/11/23/bacteria_can_take_pictures_of_themselves/The notorious E. coli bug made its film debut Wednesday. That's when researchers at the University of California, San Francisco and the University of Texas announced in the journal Nature that they had created photographs of themselves by programming the bacteria -- best known for outbreaks of food poisoning -- to make pictures in much the same way Kodak film produces images.
Chen2005barticleArtificial cell-cell communication in yeast Saccharomyces cerevisiae using signaling elements from Arabidopsis thalianasynthetic biologyhttp://www.nature.com/nbt/journal/vaop/ncurrent/full/nbt1162.htmlChen, Ming-Tang ; Weiss, RonNature biotechnology.2005Nov20advanced online publication121551--155510.1038/nbt11621087-0156
Pennisi2005articleSYNTHETIC BIOLOGY: Synthetic Biology Remakes Small Genomessynthetic biologyhttp://www.sciencemag.org/cgi/content/full/310/5749/769Pennisi, ElizabethScience2005Nov043105749769--770
ref238electronicQualitative Reasoning in biology - symposium collectionsynthetic biologyhttp://monet.aber.ac.uk:8080/monet/docs/pdf_files/aime_03/mbqr-aime03.pdf
ref239electronicWelcome to Synthetic and Systems Biologysynthetic biologyhttp://www.ssbjournal.com/Journal Homepage
ref240articleCombining two genomes in one cell: Stable cloning of the Synechocystis PCC6803 genome in the Bacillus subtilis 168 genomesynthetic biologyhttp://dx.doi.org/10.1073/pnas.0503868102Proceedings of the National Academy of Sciences of the United States of America2005Nov011024415971--1597610.1073/pnas.05038681020027-8424
ref241electronicVIROLOGY: Resurrected Influenza Virus Yields Secrets of Deadly 1918 Pandemic -- Kaiser 310 (5745): 28 -- ScienceAvianFluhttp://www.sciencemag.org/cgi/content/summary/310/5745/28
Simpson2004barticleRewiring the cell: synthetic biology moves towards higher functional complexity.synthetic biologyhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15491797&query_hl=4Simpson, Michael L.Trends Biotechnol2004Novxx2211555--55710.1016/j.tibtech.2004.09.003Nice overview of the present state of the field and some of its future research goals0167-7799
Pedraza2005barticleNoise propagation in gene networks.Synthetichttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15790857&query_hl=12Pedraza, Juan M. ; van Oudenaarden, AlexanderScience (New York, N.Y.)2005Mar2530757171965--196910.1126/science.11090901095-9203
Elowitz2002articleStochastic gene expression in a single cell.synthetic biologyhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12183631&query_hl=7Elowitz, Michael B. ; Levine, Arnold J. ; Siggia, Eric D. ; Swain, Peter S.Science2002Aug1629755841183--118610.1126/science.10709191095-9203
Guet2002barticleCombinatorial synthesis of genetic networks.networkhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12029133&query_hl=7Guet, Călin C. ; Elowitz, Michael B. ; Hsing, Weihong ; Leibler, StanislasScience.2002May2429655721466--147010.1126/science.10674071095-9203
Elowitz2000carticleA synthetic oscillatory network of transcriptional regulators.synthetic biologyhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10659856&query_hl=7Elowitz, M. B. ; Leibler, S.Nature.2000Jan204036767335--33810.1038/35002125Fundamental paper in Synthetic Biology0028-0836
ref247electronicpicrender.fcgi (application/pdf Object)synthetic biologyhttp://www.pubmedcentral.nih.gov/picrender.fcgi?artid=550990&action=stream&blobtype=pdf